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2. [PDF] 2024 SOD Research Day - OHSU
Mar 7, 2024 · ... N14D, N76D, and N143D deamidation mimics were glutathionylated by ... Co-Authors: Matthew Logan, Jade Wong, Steven Lewis, Carmem Pfeifer.
3. The Relationship Between Glutamate Dynamics and Activity-Dependent ...
We thank Bimal Tennakoon, Vanessa Strong, and Jade Quirion for technical assistance; and the animal care staff at Memorial University for assistance with animal ...
The spatiotemporal dynamics of excitatory neurotransmission must be tightly regulated to achieve efficient synaptic communication. By limiting spillover, glutamate transporters are believed to prevent excessive activation of extrasynaptically located ...
4. Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and ...
Feb 2, 2021 · Our study provides new insights on the cytotoxic function of MAIT cells in SARS-CoV-2 infection and the critical role of the IFN-α–IL-18 shift in monocytes and ...
Immune system dysfunction is paramount in coronavirus disease 2019 (COVID-19) severity and fatality rate. Mucosal-associated invariant T (MAIT) cells are innate-like T cells involved in mucosal immunity and protection against viral infections. Here, we studied the immune cell landscape, with emphasis on MAIT cells, in cohorts totaling 208 patients with various stages of disease. MAIT cell frequency is strongly reduced in blood. They display a strong activated and cytotoxic phenotype that is more pronounced in lungs. Blood MAIT cell alterations positively correlate with the activation of other innate cells, proinflammatory cytokines, notably interleukin (IL)-18, and with the severity and mortality of severe acute respiratory syndrome coronavirus 2 infection. We also identified a monocyte/macrophage interferon (IFN)-α–IL-18 cytokine shift and the ability of infected macrophages to induce the cytotoxicity of MAIT cells in an MR1-dependent manner. Together, our results suggest that altered MAIT cell functions due to IFN-α–IL-18 imbalance contribute to disease severity, and their therapeutic manipulation may prevent deleterious inflammation in COVID-19 aggravation. Severe COVID-19 is characterized by hyperinflammation, and there is a need for accurate predictive biomarkers of progression. Lehuen et al. demonstrate that patients with severe COVID-19 show a dramatic loss of MAIT cells, and those that do remain are in a highly activated state.
5. The relationship between glutamate dynamics and activity-dependent ...
Feb 5, 2020 · This Early Release article has been peer-reviewed and accepted, but has not been through the composition and copyediting processes.
6. [PDF] Early tissue damage and microstructural reorganization ...
Jul 26, 2017 · ... n14d = 3, n21d = 6) and (D) the diameter of initial axons and stem ... Fluoro-Jade B (FJB, Millipore, Schwalbach, GER) staining was ...
7. [PDF] Real Estate Assessment Roll - Accurate Assessor
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8. Shaft Jade 14mm - DVO Suspension
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9. Equal Emp't Opportunity Comm'n v. Mavis Disc. Tire, Inc. - Casetext
Sep 11, 2015 · Police Asian Jade Soc. of N.Y. & N.J. Inc. v. Port Auth. of N.Y. ... n. 14 (D.Ariz. Sept. 29, 2008). Defendants' retention procedures ...
Read Equal Emp't Opportunity Comm'n v. Mavis Disc. Tire, Inc., 129 F. Supp. 3d 90, see flags on bad law, and search Casetext’s comprehensive legal database
10. China Travel | Best Holiday & Tour Packages
Nov 1, 2018 · Jade Buddha temple & Maglev train, SEND INQUIRY. Dream China (Beijing, Xian & Shanghai ). Tour Highlights, 8 N / 9 D. Valid Till : 31st March ...
6 Packages Available
11. [PDF] The Vidette - Tishomingo County
n-14-d-26-pd. FOR SALE- 2 Female regis- tered Toy Poodles 1 black, 1 ... CIERRA JADE COLE. (ROBERTS),. PETITIONER. CAUSE NO: CV2013-000347-. T1-". NOTICE ...
12. [PDF] in a mouse model of stroke - TSpace
Nov 22, 2017 · Fluoro Jade (FJ) C (stock solution: 25 mg FJC in 250. mL dH2O ... task acquisition (trial 8) compared to controls (n=14). D) No significant ...